1. To cease to possess or to have something; such as, a job, a home, or anything that is wanted or valued: The mayor is losing his political support.
2. To be the cause of someone's failure to obtain, to win, or to maintain something: They made mistakes that lost the game for Jamie's team.
3. To be unable to find someone or something; usually, only temporarily: When Jim's mother was leaving the house, she reminded him not to lose his keys and to hold her hand because she didn't want to lose him.
4. To fail to win a victory at something; that is, a contest, an argument, a war, a game, or in a legal court: One careless statement lost the election for Shannon.
5. To be worse off, or worse off by a particular amount of money, as the result of a financial transaction or through an expenditure exceeding a person's income: They lost millions when the stock markets crashed.
6. To experience a reduction in something; such as, weight or heat: After dieting and working out, Mildred lost twenty percent of her weight.
7. To cease having a quality, belief, attitude, or characteristic: Sorry, but Henry has lost the will to live.

Nadine was afraid that she was losing her sanity.

8. To cause a decrease in a person's ability or a physical sense which may be caused by illness or an accident: Marvin temporarily lost the feeling in his fingers after having hit his funny bone very hard while playing football.
9. To waste or to fail to take advantage of something; such as, time or an opportunity: Scot doesn't want to lose the opportunity of getting the right job.

Leila lost no time in getting the project started.

10. Being unable to control an emotion or to maintain one's composure: Marcy loses her temper too often and too easily.
11. To suffer the passing away of someone because of death; such as, a loved one, a patient, or a baby before its birth: Our country has lost thousands of young men during the war on terrorism.
12. To succeed in escaping from or getting away from someone who is in following or chasing a person: Dee tried to lose the guy who was following her by turning down a side street and going into a restaurant so she could call the police for help.
13. To be unable to see or to hear someone or something any longer: Virginia has lost her hearing, but she doesn't want to use a hearing aid.
14. To fail to make someone understand something: During Hank's explanation, the woman he was talking to said that she had lost him; that is, she didn't understand what he was talking about.

Jim and Jenny understood the first part of the lecture very well; but when Rodney started to talk about advanced computer programming, he was losing his listeners completely.

15. To get rid of someone or something that is unwanted or undesirable: Please lose those extra spaces between the lines.

Apparently Selma can't lose that cold.

16. To fail to keep or to get something that is valued or desired: Simona was told that if she didn't invest in that company, she would be losing out on a great opportunity to gain more money.